This chapter examines business involvement in the Latin American Free Trade Association (LAFTA), the Andean Community, the Southern Common Market, and the Pacific Alliance (PA). It looks at the existence of an institutional place for entrepreneurs in regional agreements; how did entrepreneurs organize to deal with integration? and what was the entrepreneurs' position regarding the development model embedded in each agreement? The chapter discusses the elements of continuity and changes in their involvement and specifies some explanatory variables of the entrepreneurs' interaction with Latin American regional integration. In 1960, LAFTA changed the national horizons of entrepreneurs' economic activities when it established the goal of developing a free trade zone. Entrepreneurs had a proactive participation on Andean regulation of foreign direct investment and institutional reforms of the Cartagena Agreement. In PA, entrepreneurs' involvement in regional integration seems to be embedded in a strong relationship with their own states and the export-led development model.