Hadjadj, J. et al. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science https://doi.org/10.1126/science.abc6027 (2020). Li, Q. et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N. Engl. J. Med. 382, 1199–1207 (2020). CAS Article Google Scholar Chen, G. et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J. Clin. Investig. 130, 2620–2629 (2020). CAS Article Google Scholar Huang, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395, 497–506 (2020). CAS Article Google Scholar Mehta, P. et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395, 1033–1034 (2020). CAS Article Google Scholar Download references This work is supported by the National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2019ZX09721001-004-004). These authors contributed equally: Zhenling Wang, Hailong Pan State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China Zhenling Wang & Boguang Jiang Department of Quality Management, China National Biotec Group Company Limited, 100020, Beijing, China Hailong Pan You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Zhenling Wang. The authors declare no competing interests. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Wang, Z., Pan, H. & Jiang, B. Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients. Sig Transduct Target Ther 5, 198 (2020). https://doi.org/10.1038/s41392-020-00306-4 Download citation Received: 31 July 2020 Revised: 10 August 2020 Accepted: 12 August 2020 Published: 14 September 2020 DOI: https://doi.org/10.1038/s41392-020-00306-4