The objective of this work was to evaluate the knowledge and attitudes of health workers in the Colombian Caribbean for the care of COVID-19. The study is inferential, cross-sectional, quantitative; who used an instrument previously validated and used by Shi et al. The population was made up of healthcare workers who work in the health sector of the cities of Cartagena de indias and Barranquilla. A high percentage indicates that they do have the knowledge to care for infected patients (80.21%). The main reasons for not having care provision is not having adequate protection elements (66.09%) and fear of contagion or infecting their family (33.91%). In conclusion, greater attention should be paid to the knowledge and activities of healthcare personnel in the Colombian Caribbean health sector for the care of patients infected with COVID-19.