The research aimed to describe the level of risk against the consumption of psychoactive substances in urban public transport drivers. It is a descriptive cross-sectional quantitative study with a sample of 214 drivers chosen through simple random sampling. The ASSIST V3.0 Test was applied, obtaining positive results against tobacco consumption (57.9%), alcohol (89.7%), cannabis (8.4%), tranquilizers (4.7%) and hallucinogens (.9%). Tobacco is the substance that represents the highest level of risk in more than half of the cases (52.8%), which indicates the possibility in drivers of presenting future health problems anddependence on the substance. The importance of the formulation of a sustainable policy and the development of programs that prevent the consumption of psychoactive substances and promote healthy lifestyles are concluded, so that the health and well-being of drivers is guaranteed.