The objective of this work was to analyze the relationship between personality variables and quality of life in students of the Minuto de Dios University Corporation. Method: A quantitative study was carried out, using a correlational design with descriptive scope that includes univariate analyzes (statistical, descriptive and frequencies), bivariate analyzes, including comparative analyzes (contrast of means and correlational analyzes). The sample was made up of 360 participants, who were students from the Minuto de Dios University Corporation. Random intentional sampling was applied between the degrees of Psychology, Child Pedagogy and Administration in Occupational Health. Results: For the dimensions of neuroticism and extraversion, high levels of anxiety and emotional instability were found in the sample, which could demonstrate low impulse control. Regarding the dimensions of psychoticism and neuroticism, the scores show a high degree of impulsivity and difficulty in admitting guilt when carrying out a certain action. Conclusions: Based on the results, the personality variables and quality of life of the university students of the Minuto de Dios University Corporation show a clear relationship of dependency with their lifestyles and that are identified through the conditions of quality of life evaluated.