The supply chain has changed over the years, and with technological innovations, many tools have been developed today that seek the optimization of time and costs in this process; unfortunately, there is still a gap between companies with the capacity to implement these developments and small and medium-sized companies. This chapter seeks to show how artificial intelligence has emerged with a portfolio of solutions applicable to the supply chain management, some of which are still under development but are aimed at simplifying and automating these processes. The chapter will define these concepts to then show the different applications that artificial intelligence has in the management of the supply chain to conclude and pose the future challenges that the supply chain will face and that can be solved with the use of technologies innovative and disruptive.