Potato (Solanum tuberosum L.) is a demanding crop regarding fertilization practices, and its productivity also depends on the variety used, environmental conditions, soil fertility, and crop management. The aim of this study was to investigate the effect of the interaction of nitrogen and phosphorus fertilization sources on potato crop yield. A randomized block design with a 3×3 factorial arrangement, nine treatments, and four repetitions was established. INIA-303 Canchan was the variety evaluated using three nitrogen fertilization sources: ammonium nitrate (AN), ammonium sulfate (AS), and urea. Also, three phosphorus sources were used: monoammonium phosphate (MAP), diammonium phosphate (DAP), and triple superphosphate (TSP). Total yield, commercial yield, tuber number per plant, and tuber weight per plant were studied. INIA-303 Canchan variety showed positive responses to the combinations of nitrogen and phosphorus fertilization according to the soil and climate conditions where the research was carried out. AN+DAP was the combination with the highest total yield, commercial yield, number, and weight of tubers per plant (P<0.01).The fertilization mixtures of AN+DAP, AS+MAP, and AN+MAP, applied on the INIA-303 Canchan potato variety, can be recommended to achieve yields between 32.45 t ha-1 and 33.98 t ha-1