This work addresses the development of the Flipped learning model in Virtual Learning Environments based on the case study of the Minuto de Dios University.To do this, an account of the concepts and strategies that guide this educational trend is carried out, highlighting the creation of a study unit with the aim of energizing educational practice, improving the teacher-student relationship and evaluating the Flipped learning model in virtuality.Then, through a mixed approach (qualitative and quantitative) of an exploratory nature, input and output questionnaires are applied in contrast to a focus group to recognize the evaluations, perceptions, contributions, improvements and difficulties evaluated in the development of the unit.As main conclusions, the relevance of applying the Flipped model under the e-learning modality to strengthen the notion of feedforward and e-moderating, as actions that make teaching practice more flexible, is also found a positive assessment by students facing to the training unit created by facilitating active learning in the e-learning modality.