Introduction: Palpebral neoplasms in felines have a low prevalence but a high degree of malignancy. Various therapeutic techniques have been described and choosing them depends on the tumor type and the patient. In human medicine, cryotherapy is considered as an important method for treating external neoplasms such as hemangioma due to its effectiveness and low adverse effects. Patient and methods: Herein we describe the clinical case of a 10-year-old domestic cat with a unilateral palpebral hemangioma that was treated with cryotherapy. Results and Conclusion: The patient showed complete recovery and had minimal side effects. Cryotherapy could be an effective tool for surgical treatment of feline patients with similar neoplasias.