Solubility of meloxicam in {acetonitrile + water} mixtures at five temperatures from 293.15 K to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. Non-linear enthalpy–entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative slope in the composition region 0.00 < x1 < 0.20 and variant slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich and acetonitrile-rich mixtures but preferentially solvated by acetonitrile molecules in mixtures 0.26 < x1 < 0.60.