This article covers the different concepts that have emerged in business management and their relationship with information and communication technologies (ICTs) management, after the growing impact that has been given by disruptive thinking on how to create business and provide goods and services. The following topics are dealt with throughout the discussion: The importance of the analysis of information and the innovation environment as input for decision making; the business model and its adequate evolution as a central axis that allows sustainability and competitiveness; and the knowledge-technology relationship as a differentiating factor which adds value to the organizations. In addition, a reflection is made on the impact of digital disruption on the social and organizational environment. Some cases of success and failure of business disruption and digital trends in Latin America are highlighted.