Abstract Annual defoliation and refoliation cycles that occur in rubber trees after 5 years of age have a strong interaction with foliar diseases attacks. The rubber phenology was studied in the eastern plains of Colombia, in the municipality of Puerto López, department of Meta, where variables such as foliar density, percentage of leaves in stages A, B, C and D and flowering density were evaluated in clones IAN 873, FX 3864 and RRIM 600, between August 2016 and September 2018. All three clones showed a foliar density higher than 80% with leaves in stage D, between March and December (weeks 12–50 of the year). The defoliation started in the last weeks of the year, with the beginning of the dry season. The refoliation extended until mid-March (week 11) in 2017, and until February (week 6) in 2018. The presence of leaves in stages A, B and C during 8–13 weeks was observed at the plantation level, according to the clone and the evaluation year. The duration of the refoliation per tree was on average 6.73 ± 0.22 weeks in 2017 and 4.42 ± 0.39 weeks in 2018. Flowering coincided with refoliation, during a period of negative water balance and high solar radiation. Expansion of inflorescences was observed in the first weeks of the year between January and March, with the absence of reproductive development when the crop was dominated by leaves in stage D.