The authors in this chapter describe the approach, purpose, and work of the International Research Center for the Development of Education (CIIDE per the acronym in Spanish) as an illustration of a glocanal internationalization effort involving research and flows of faculty and administrators between a non-elite university in the Global South and a research-intensive university in the Global North. CIIDE is a joint effort between the College of Education at the University of Missouri in the U.S. and the main campus of the Corporación Universitaria Minuto de Dios (UNIMINUTO) in Bogotá, Colombia. In this chapter, first, the authors review the two theoretical lenses informing the analysis of the conceptualization and work of CIIDE, which are the glocanal agency heuristics developed by Marginson and Rhoades (2002) and the work of George Mwangi (2017) on mutuality in internationalization. Then, the authors present the actual work of CIIDE, including its origins and daily operations, followed by an analysis of CIIDE´s glocanal agency heuristics and mutuality.