The coronavirus disease (COVID-19) spread rapidlyaround the world. Two types of approaches have beenapplied to use of face masks as a tool to prevent the spreadthis disease in society. The aim of the systematic reviewwas to assess the effectiveness of face masks against thenovel coronavirus. A literature search was performed usingdifferent databases until April 30, 2020. Search termswere ‘facemasks’, ‘novel coronavirus’, and ‘healthcareworkers’. Five studies were included in the systematicreview. A study stated that no difference between surgicaland cotton masks. Also, two studies have emphasized theuse of surgical masks or N95 respirators by medical staff,and two other studies emphasized the use of any type offace mask by general public. More studies in controlledcontexts and studies of infections in healthcare andcommunity places are needed for better definition of theeffectiveness of face masks in preventing coronavirus.