Introduction: Bone regeneration in post-extraction sockets has been frequently used with bone grafts, some authors have proposed the use of autologous dentin as a substitute for these bone grafts. Materials and methods:An extraction and an autologous dentin regeneration was performed in a 28-year-old patient on tooth 21, it was evaluated radiographically at 9 months and subsequently histological study, to evaluate the results at a microscopic level.Results: Clinically good tissue integration was observed.In the biopsy, a physiological bone remodeling was observed, where the dentin particles are biologically integrated with the adjacent alveolar bone.Discussion: Bone crest volume was preserved, soft tissues healed properly and without any signs of inflammation Conclusions: In this case report, an adequate integration of dentin with the patient's bone tissues was observed.There is still limited evidence on the use of autologous dentin as a bone substitute, controlled clinical trials are required to assess the outcome of the implementation of its use.