The spread of the COVID-19 has generated a global rupture of routines and everyday life. The situation for informal settlements is exceptionally delicate due to their socio-economic conditions and the restrictions imposed by the quarantine to contain the virus. In this brief piece, we present our reflections about the quarantine in relation to urban informality. Most of our discussion is centered on an informal settlement in Bogotá: El Codito sector. We reflect on the quarantine as a privilege that not everyone possesses, as well as on the materiality of the quarantine and the possible suspensions of informal powers. We suggest considering the potentialities and capacities of informal settlements to help flatten the curve and navigate the crisis.