SARS -CoV -2 is a new member of coronaviruses that its sudden spreading put the health care system of most countries in a tremendous shock. For controlling of the new infection , COVID - 19 , many efforts have been done and are ongoing to defeat this virus in the combat field. In this review , we focused on how the immune system behav es toward the virus and the relative possible consequence s during their interaction s. Then the therapeutic steps and potential vaccine candidates have been described in a hope to provide a better prospective of effective treatment and preventive strategies to the novel SARS -CoV in near future