The increase of studies in recent years on Autism Spectrum Disorder and its employability, is an opportunity for research focused on social and occupational inclusion of this group. The lack of inclusive jobs for this population is partly due to the absence of frameworks, methodologies and tools that allow the development of solutions for their adaptation. The main contribution is focused on the development of a model for the design of jobs for the empowerment of workers and articulated from the enactive paradigm in the context of Vygotsky's Activity Theory (AT), Ashby Variety Law (VL) and, supported by the Design for X (DfX) with a proposal of application to a case study for the industry 4.0. The proposed case study focuses on the design for the adaptation of an accessible workplace within an aeronautical component manufacturing plant that incorporates workers with ASD, with the intention of promoting the socio-labour development and inclusion of these individuals in an industrial, technological and innovative environment. KeyWords: Autism spectrum disorder (ASD); inclusive workplace design; Activity Theory (AT); Required Variety Law (RVL); occupational environment; design for ASD 4.0; design for X (DfX).