Abstract In this paper we present the main results of the master thesis in applied mathematics of the second named author, which was supervised by the first named author. Such results, and for instance this paper, concerns to some differential and algebraic results involving natural matrices. The problem of solving differential equations is very ancient and is very important to get explicit solutions of differential equations to be applied in physics and other areas. In this paper, as well in the master thesis, we study the differential and algebraic structure of linear differential equations with natural matrix coefficients and generalizations. These results are original and important for researchers interested in differential algebra and applications of differential equations.