This research demonstrates how the orientation to organizational learning affects the innovation and performance of the Colombian micro, small, and medium (MSMEs) enterprises, based on a study with 403 Colombian MSMEs, pretending that the results allow the government sector and the academy to design strategies maintain or improve, as appropriate, innovative and learning practices within these organizations. Two hypotheses were raised: 1) learning orientation positively influences business performance and 2) learning orientation positively influences business innovation. The two hypotheses are demonstrated after performing a multiple regression analysis and a broadly significant relationship was evidenced both between the orientation to learning and innovation and in each of the dimensions that make it up: innovation in products/services, processes, and management.