ABSTRACT We performed phylogenomic analysis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) from 88 infected individuals across different regions of Colombia. Eleven different lineages were detected, suggesting multiple introduction events. Pangolin lineages B.1 and B.1.5 were the most frequent, with B.1 being associated with prior travel to high-risk areas. Article Summary Line We sequenced 88 genomes of SARS-CoV2 from Colombia finding 11 lineages and eight different introduction events