Abstract Background Pulmonary vein isolation (PVI) is the mainstay of catheter ablation (CA) for paroxysmal atrial fibrillation (AF). However, for persistent and long‐standing persistent AF, there are no established strategies to improve the success rate of CA. Despite studies indicating that prophylactic cavotricuspid isthmus (CTI) ablation provides no or limited incremental benefit in patients with AF, it is still routinely performed worldwide. Objective We sought to examine whether CTI ablation for AF is associated with improvement in recurrence of all‐atrial arrhythmias, compared with PVI alone in patients with and without typical atrial flutter (AFL). Methods A systematic review of PubMed, Cochrane, and Embase was performed for clinical studies including AF patients, reporting outcomes of CTI + PVI versus PVI alone. The primary efficacy endpoint was recurrence of all‐atrial arrhythmias. Results Five studies comprising 1400 patients undergoing CTI + PVI versus PVI alone were included; 1110 patients had AF without AFL, and 290 patients had coexistent AF and AFL. After a mean follow‐up of 14.4 ± 4.8 months, CTI + PVI was not associated with improvement in recurrence of all‐atrial arrhythmias when compared with PVI alone (risk ratio [RR]: 1.29; 95% confidence interval [CI]: 0.93–1.79; p = .13). In the subgroup analysis, there were no differences between both groups in patients with AF without AFL (RR: 1.55; 95% CI: 0.96–2.48; p = .07), and in patients with AF and AFL (RR: 0.91; 95% CI: 0.6–1.39; p = .68). Conclusion In AF patients, irrespective of the presence of typical AFL, additional CTI ablation is not associated with improvement in recurrence of all‐atrial arrhythmias, compared with PVI alone.