Background: Squamous cell carcinoma affects subjects between the sixth and seventh decade of life. However, there are growing reports on the involvement of young adults.
 Clinical Cases: Two male patients aged 40 and 55, with no history of tobacco consumption and occasional alcohol consumption. They presented an exophytic ulcer and a white plaque on the lateral border of the tongue, the first diagnosed as moderately differentiated squamous cell carcinoma without HPV DNA genotypes and the second as leukoplakia without dysplasia.
 Conclusions: Risk factors commonly associated with potentially malign disorders and oral cancer, such as smoking and alcohol consumption, were not involved in the present cases. Therefore identify clinical, histopathological and molecular findings, allows the early detection of them, improving the prognosis of these patients.