Latin America is suppose to have significant advantages over other developing regions, such as Asia and Africa, given the time where the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), causing the Coronavirus Diseases 2019 (COVID-19), arrived, mainly from Europe. This occurred on February 26, 2020. Then, multiple previous measures were taken in order to prevent and mitigate the impact of pandemic in the region. In the current mini-review update we discuss the possibilities of “crushing” the transmission curve of COVID-19 in the region after two months of the arrival of this emerging coronavirus.