Aims Debridement of infected walled-off pancreatic necrosis (WOPN) is indicated to treat ongoing infection and sepsis-related multi-organ failure. The lack of dedicated and effective accessories results in the need for time-consuming repetitive procedures. The aim of this prospective international multicenter study is to evaluate the use of a new 3.1 mm flexible microdebrider catheter (EndoRotor) to remove solid debris under direct endoscopic visualization in patients with WOPNs.