Infection Control reported three cases of Kpn-KPC with a probable relation among them in the adult intensive care unit UCI-A in the hospital “Dr. Verdi Cevallos Balda” from Portoviejo, Manabi, Ecuador. This observational and descriptive study aims to characterize this outbreak, according time, space and person. Laboratory tests are analyzed, and the correlation between cases and positive result of the study is shown. Clinical epidemiological aspects of patients with Kpn-KPC carbapenemases producing Klepsiella pneumoniae infection were recorded (January to March 2017). The ICU-A Adult Intensive Care Unit and family environment are a probable factor of dissemination of the disease. The isolation of KPC is an alternative to clinical suspicion. The implementation of infection control measures is essential to reduce nosocomial transmission of Kpn-KPC.