Losartan is a highly consumed antihypertensive worldwide and commonly found in effluents of municipal wastewater treatment plants. In the environment, losartan can promote harmful effects on organisms. Thus, an option to face this pollutant is the treatment by photochemical advanced oxidation processes. This dataset has two main components: 1) theoretical calculations on reactivity indexes for losartan, and 2) degradation of the pollutant throughout TiO