Currently the world is going through one of the worst health crises secondary to the infection by a new highly transmissible and deadly coronavirus, which has impacted multiple aspects. It has been generally established that the severity of the infection is associated with old age and comorbidities such as hypertension and diabetes. On the other hand, obesity at this time represents one of the greatest threats to the health sector, due to its strong relationship with morbidity and mortality at the cardiometabolic level which leads to a high cost of the disease. This article seeks to warn about what some experts havecalled the “clash of two pandemics”, this given the increasing prevalence of obesity worldwide, where our country is not exempt, which could be related with a greater number of people vulnerable to COVID-19 infection and related respiratory complications and thus avoid catastrophic outcomes.