T he pandemic caused by a novel severe acute respi- ratory syndrome coronavirus 2 (SARS-CoV-2) can cause several gastrointestinal (GI) symptoms.A recent systematic review showed a prevalence of GI symptoms in 17.6%.The most frequent manifestations were anorexia (26.8%), diarrhea (12.5%), nausea/vomiting (10.2%), and abdominal pain (9.2%), 1 and recent reports showed the detection of viral RNA in stools for prolonged periods (70.3%). 1 We established the frequency and impact of GI symptoms, and viral presence in stools among Chilean patients infected with SARS-CoV-2. MethodsWe used information available from the Chilean Ministry of Health.SARS-CoV-2 infection was confirmed by a quantitative real-time reverse transcription-polymerase chain reaction from nasopharyngeal swab (NPS).We analyzed a convenience cohort (2 hospitals, Faculty-of-Medicine, Pontificia Universidad Católica de Chile/FM-PUC) of SARS-CoV-2-infected patients, including their sociodemographic and clinical data, and biological samples (nasopharyngeal swab, sputum, and stools), which were collected for quantitative real-time reverse transcription-polymerase chain reaction analyses, and used the cycle threshold (C T ) as a surrogate marker of viral load.The protocol was approved by the FM-PUC Scientific Ethics Committee.