Patients with dementia have pathology that affects different frontal lobe (FL) areas. Understanding the clinical spectrum of frontal components in cortical dementia still remains unclear. To identify if signs and symptoms in dementia are associated with specific subtypes of FL cognitive processes as well as the related anatomical location through a clinical approach based on Botez and Stuss clinical and anatomical classifications maps. Frontal syndromes in 20 patients with dementia met the NINCDS–ADRDA, and DSMIV criteria, for Alzheimer Disease (AD), Mild cognitive Impairment (MIC) and FTD (F=12;M=8). Patients from San Ignacio Hospital Memory Clinic went through a consensus diagnosis (Neurology, Geriatric, Psychiatry and Neuropsychology). A Neurologic Inventory (NI), oriented to map a multidimensional profile of behavioral, and cognitive signs was done. Symptoms assessed included, among others: delusions, agitation/aggression, depression, anxiety, elation/euphoria, apathy/indifference, disinhibition, irritability/lability, aberrant behavior, attention, anomia, anosognosia, concreteness. Through the NI three types of classification was performed: right, left or bilateral frontal area (Classification1: C1); polar, lateral, superior and inferior medial surface and different regions (C2). A third localization (C3) was suggested: precentral, premotor, prefrontal and others connecting frontal areas (Broadmman). Anomia, depression, attention disorder, anxiety, anosognosia and behavioural disorders were frequent earlier frontal symptoms in FTD and all patients. Despite diagnosis, patients' signs and symptoms showed heterogenous profiles inferred by frontal disturbance. C1 identified better laterality when language compromise was present. C2 can classify symptoms with surfaces but not regions proposed by Stuss (C2). Botez (C3) identify better neurological signs. Behavioral, linguistic and affective disorders are symptoms that could advocate a different profiles and localizations of main frontal dysfunctional areas: C1 and C3 could become a useful tool to identify early neurological markers of a frontal dysfunction in patients with dementia. If sample is increased, subtypes of FTD could be highlighted. C2 requires a correlation with cognitive processes measured through formal neuropsychological tests since IN does not included specific cognitive abilities. Neurological assessment should be completed with functional images to clarify these proposes.