Fifteen Latin American countries are analyzed considering six factors that reflect their progress with respect to research and development, science and technology, education and innovation. These factors are studied as inputs and outputs in a technical efficiency analysis of their economies using Data Envelopment Analysis (DEA). As inputs, the percentage of Gross Domestic Product (GDP) contributed to education and research and development expenses, in addition to the number of universities in each country. while ouputs are Information and Communication Technologies (ICT) services and high-tech exports, as well as the Global Innovation Index. The data were collected from the World Bank, Economic Commission for Latin America and the Caribbean (ECLAC), World Intellectual Property Organization (WIPO) and the Webometrics Ranking of Universities. It was obtained that the Latin American countries present different performances considering the contribution of the GDP for research and development expenses, being this the main input that contributes with the High-technology exports in the studied Latin American countries.