Successfully developing a new product, service or production process for commercial purposes involves complex and dynamic changes, and therefore requires conditions of knowledge management that fosters innovation. In this sense, processes by which knowledge is created and exploited in the firm constitute key competence and source of innovation capabilities. The objective of the study is to examine the relationship between conditions of knowledge management and innovation capability. The sample consists of 102 Colombian new technology-based firms. According to results, conditions of knowledge management has a positive effect on innovation capability, specifically flexible structure, information and communications technology, strategic purpose, and competitive environment. The results help firms, especially those that require a lot of knowledge and carry out their activities in uncertain and dynamic environments, to management and understand how the processes of innovation capability are influenced by the conditions of knowledge management.