Introduction: Renal biopsy (BR) provides invaluable information and histopathologic correlation to clinical features of patients with renal impairment. However this study is scarce in our population. The main objective was to determine clinical and demographic characteristics of patients undergoing percutaneous renal biopsy. Methods: Retrospective study that included 245 patients who underwent percutaneous renal biopsy at the department of nephrology of Carlos Andrade Marin Hospital. Results: The most frequent histopathologic diagnoses were: lupus nephritis (28.4%), membranous glomerulonephritis (16.7%), membranous-proliferative glomerulonephritis (9.4%) and mesangial proliferative glomerulonephritis (8.2%). We assessed the association between histological diagnosis with sociodemographic variables as well as with clinical variables such as past history of type 2 diabetes mellitus, hypertension, systemic lupus erythematosus, glomerular filtration, prebiopsy and post-biopsy hemoglobin level and proteinuria. Discusion: Histopathologic diagnoses are associated with sociodemographic and clinical variables, suggesting the need to perform studies in other hospitals to build consensus and guidelines for patients that need undergoing percutaneous renal biopsy to reach histopathologic diagnosis.