This study aimed to analyze the effect of the area size and location of openings for natural ventilation on the temperature and relative humidity inside a typological facility for coffee wet processing that have been using in Colombia and some South America Countries as well, with mechanical drying inside, using modeling with computational fluid dynamics modeling, in order to find the best suitable condition for preserve the quality of the coffee parchment. A significant effect was found regarding the area and location of the openings for natural ventilation on the internal hygrothermal environment, but no significant effect was found on the temperature. It was also found that the chimney effect plays a decisive role in the mass transfer of water vapor and heat to the outside of the building, and helping to maintain a suitable internal environment for the preservation of coffee.