Thin reinforced concrete (RC) walls with single layer reinforcement have been used for houses and buildings in several Latin American countries. Although some design codes include recommendations for squat thin walls in low-rise constructions, its seismic performance has not been validated adequately in past earthquakes. This article presents the results of an experimental campaign of nine full-scale specimens conducted to characterize the influence of the steel type, the reinforcement ratio, and the wall thickness on the seismic behavior of squat thin RC walls with single layer reinforcement. Both welded wire and deformed bars were used as web reinforcement. Experimental results are used to develop nonlinear models to assess the seismic behavior of a prototype two-story house with welded wire reinforcement and deformed bars by means of incremental dynamic analyses. The experimental results show that the type of steel has the largest influence on wall seismic performance. The numerical results suggest that RC walls with single layer reinforcement are suitable for housing applications up to two stories in high seismicity regions, particularly walls detailed with deformed bars.