Cardiovascular diseases are the main cause of mortality all over the world. Their incidence and prevalence increase with age and different risk factors. The majority of factors are closely related to the lifestyle; aspects such as hypertension, diabetes mellitus, obesity, and stress are more prevalent day by day and vary according to the population and its geographical location. The researchers made a revision on international and national epidemiology of the acute coronary syndrome and it has changed over the years. The study included literature published in both English and Spanish retrieved from different databases. For this particular case, 50 articles focused on the epidemiologic impact of the acute coronary syndrome were reviewed. After a detailed revision, it can be said that the cardiovascular disease, which has been increasing during the past years, remains as the first cause of morbidity and mortality at the worldwide level. This syndrome causes more deaths in all events, with different incidence, age in which it takes place, economic impact and risk factors, depending on each region. The modifiable risk factors are still very important in the development of cardiovascular diseases