Abstract The Quindío river is the main water source of the Quindío department, Colombia, which supplies water to 410000 people. Therefore, the study of its water quality is extremely important. If pollution is not monitored and controlled in this water source, diseases could affect the population of people that use the river as a source of water. For this reason, fieldwork was carried out in an area of the Quindío river where the total suspended solid and hydrogen potential parameters were studied. In order to analyze the data that was obtained in the fieldwork, the spine interpolation needed to be performed to generate a new sample where the spatial data was equidistant. To determine the relationship between the total suspended solid and hydrogen potential parameters, two regular time series were built and the second-order vector autoregressive model was adjusted. The model order was suggested by the statistical package Eviews.