The MQPO is an Italian self-applied questionnaire to assess the Personal Meaning Organization (PMO), theoretical construct of the personality, which is fundamental for post-rationalist cognitive psychotherapy, created by Vittorio Guidano. This article is an adaptation and validation of said instrument in the Colombian population. Method: adaptation and validation were carried out by applying the instrument to a sample of 243 university students. Results: four main factors were formed as in the original version of the test, whose internal consistency indices measured using Cronbach's Alpha ranged between .57 and .67, with a total internal test consistency of .74. In the factor analysis, according to sex, a statistically significant difference was found in the Depressive PMO (p = .043) and the Phobic PMO (p = .045), with greater tendency in men to present the former and in women the latter. Conclusion: The MQPO translated into Spanish evidenced a good internal consistency, which allows it to be used in scientific research in the Colombian university context.