At the end of the Cold War, global society thought that the clash of ideologies and the polarization of theories had been overcome. However, at the end of the twentieth century and the beginning of the twenty-first, there were clear signs that that was not the case. The first of those signs was the comeback of Marxism, which based on the humanist idea of the philosophy of praxis brings back the legacy of Jose Carlos Mariategui, Ernesto "Che" Guevara and Camilo Torres in Latin America. The article considers whether the paradigm of Marxist Humanism appropriates the principles of good life or living well to face Neoliberalism and its development project. The approach to the issue is qualitative and descriptive. Through the analysis of political discourse suggested in development criticism (Escobar 191), the article addresses the characterization of Neoliberalism and the development model. It also addresses the thesis advanced by Marxist Humanism and the strategy of cultural revolution for emancipation in Latin America. Finally, it presents how Neo-Marxists appropriate and understand good life to face Neoliberalism.