Avocado (Persea americana Mill) is a native American fruit. Its industrial processing generates a large number of wastes (leaves, peels, and seeds). These wastes are a source of bioactive compounds which have been attributed biological activities. We aim to compile scientific research on bioactive compounds of avocado pulp and wastes and their potential biological properties. Main bioactive compounds identified in pulp and wastes are polyphenols, carotenoids, tocopherols, and phytosterols. Thus, wastes extracts have reported numerous biological activities, e.g., antimicrobial, anti–inflammatory, anticancer, antidiabetic, antihypertensive. Therefore, potential applications in food and pharmaceutical industries can be issued.