Introduction: Dengue, yellow fever, malaria, and leishmaniasis are vector-borne infections.Objective: The objective of the study was to present a clinical case of severe malaria and dengue coinfection.Materials and methods: This was a descriptive study with the presentation of the clinical history and literature review.Results: A 10-year-old patient was admitted to the Hospital Militar Central in Bogotá, diagnosed with severe malaria by Plasmodium falciparum and dengue.He received intravenous fluids, acetaminophen, and three artemether-lumefantrine tablets every 12 h for 3 days.A literature review was done and the case findings were compared with what was published in databases.Conclusion: Malaria and dengue are frequent in tropical zones, but the probability of coinfection is low due to the variable presentation of these two diseases, and their prevalence depends on local endemicity.