Replacing natural aggregates (NA) for blast furnace slag (BFS) is seen as a technique that is beneficial for the environment. Additionally, in high temperature climates, rigidizing the asphalt by employing gilsonites (G) could be an alternative in order to increase rutting resistance. This study substituted in volume, part of the coarse fraction of NA for BFS in a hot mix asphalt (HMA) that employed asphalt modified with G in wet process. Physical properties of BFS are presented, as well as its chemical and mineral compositions. Additionally, physical properties of asphalt modifi ed are shown. In regards to HMAs, their resistance under monotonic load (Marshall test and indirect tensile strength test), cyclic (resilient modulus, permanent deformation and fatigue) and moisture damage (tensile strength ratio – TSR) was evaluated. All HMAs were manufactured employing the same asphalt content from the control mix. An ANOVA variance analysis was conducted. Based on ANOVA, when the NA volume is substituted with BFS, Marshall stability/ /flow relation significantly drops. However, when such substitution is carried out using G-modified asphalt, resistance under monotonic load, stiffness under cyclic load, resistance to permanent deformation and moisture damage notably increase. Fatigue resistance also increases but such increase is not statistically significant.