The Campoalegre River basin and its sub-basins present water-use conflicts. This study seeks to analyze these conflicts using a disaggregated quantitative approach, so as to better understand existing and potential water stress. We find that the estimated future flows are not sufficient to meet future demand, which will create significant water stress, particularly in certain sub-basins. A tool is provided for decision makers to identify potential future water conflicts, as well as strategies to reduce system vulnerability. This study is relevant for other watersheds where pressure on water resources may intensify due to increased water demands.