This chapter studies the dynamics of Bogotá Region based on the New Economic Geography and the recent works on economic development in two big dimensions: the economic and the spatial structure; that is, productivity and polycentrism. The central thesis, supported on an econometric exercise for SMEs in 20 cities in Bogotá-Sabana region, is that with greater strength in the interior of Bogotá and less in the city region, a transition from monocentrism to functional polycentrism is consolidating. Krugman's Edge Cities model concludes that polycentrism comes from a process of spontaneous self-organization and produces a territorial order according to the mysterious ZIP law and consistent with efficiency, equity, and sustainability.