This research examines the relationship between technological distance (DT)and four indicators of the value of innovations or new knowledge - relative position of the patent (RPP), revealed technological advantage (RTA), Herfindahl-Hirschman Patent Index (HHI) and patent cites (PC), in inter-organizational alliances of the biotechnology sector. The research was developed using the multiple correspondence analysis. The results confirm that the technological distance of the partners (DT) of the alliance is not related to the patent cites (PC) indicator. On the other hand, it was established that there is a relationship of the DT with the RTA, RPP and the HHI; however, it was observed that the DT with the RPP have a strong linear relationship, while the relationship of DT with RTA and HHI, it seems to show an inverted U configuration. In this way, statistically it is demonstrated that the technological distance, measured in terms of the difference of the knowledge bases between the organizations that make up the alliance, is a factor that is associated in a significant way to the value of innovation.