Objective: To investigate from the data analysis whether the relationship and the bond between the professional and the patient, users of alcohol and other drugs, interfere in adherence to the treatment of chemical dependency. Method: The study is based on an integrative literature review, carried out between September and October 2020, in the MEDLINE, PubMed, SciELO and LILACS databases and data and manuals available on the World Health Organization (WHO) portals. Conclusion: The interpersonal relationship between professional and patient is a means of developing the user's confidence, comfort, feeling of being respected and of being a participant in the decision- making process and this reflects in the improvement of adherence to treatment in chemical dependence.