Indigenous communities in Colombia have been characterized by an economy of subsistence, influenced by the nomadic population that has allowed them to take advantage of the abundance of the environment in which they live and by the cultural context of these communities. The authors document a project initiative to co-create a sustainable entrepreneurship model for indigenous communities, to identify sustainable income alternatives adjusted to the culture and living conditions of indigenous people. First experiences of this project took place in La Fraguita Community in the Department of Caquetá at the south of Colombia, where a social entrepreneurship incubation process was deployed, identifying different productive activities, selecting grounded organic chili pepper as a pilot for the implementation of a culture-based and local product income alternative, with added value provided by the community.