Epileptic encephalopathies make up a group of electroclinical syndromes that are characterized by to have an established presenting age, clinical neurological deterioration secondary to persistent epileptic activity and an irregular response to classical pharmacological treatments. Its etiology is variable, and its precipitating factors are controversial. Since the 90's, the role of inflammation in epilepsy has been described, through to the findings like the presence of inflammatory cells and molecules in cerebrospinal fluid and surgical specimen from affected patients.