Aims:The clinical effects of a Triticum vulgare-containing mouth gel on oral mucositis were evaluated.Presentation of Cases: Five children suffering from oral mucositis due to chemo/radiotherapy were treated with a Triticum vulgare-containing mouth gel, spreaded three times in a day as thin layer on the mucosal lesions for 14 days.Control visits were conducted at the days 4th, 7th and 14th.During each visit both the capabilty of ingesting solid food and beverage were evaluated, as well as the pain intensity -judged by VAS (Visual Analog Scale, graded 0-10).Before the treatment, the pain intensity was ranging from 8 to 10 in all subjects; at the day 4th the mean VAS value decreased to 4.6 and at the day 7th to 1.3 At the day 14th no pain was referred by all patients.At the day 4th, 4/5 patients were able to ingest liquids and food.