In this study an industrial kaolin was subjected to high temperatures for one and two hours in order to eliminate plasticity and swelling properties. This heat-treated kaolin (HTK) was then evaluated for use as a substitute for natural mineral filler (passing No. 200 sieve; 6% by total mass of aggregate) in a Hot Mix Asphalt (HMA). The Marshall stability and flow test and Indirect Tensile Strength (ITS) test were performed to evaluate responses of HMA mixtures. X-ray diffractometry (XRD) and X-ray fluorescence (XRF) tests were carried out on caolin (with and without thermal treatment). Effects of temperature and time of exposure on the penetration index (PI) and free swell index (FSI) of the HTK are also presented. Increased resistance under monotonic load and moisture damage was found when the natural mineral filler was completely replaced by the HTK. In contrast, when kaolin (K) that has not been heat-treated is used resistance and damage noticeably decrease especially in the presence of water.